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Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in growing sciatic nerve. Janeczko K. The proliferative response of S-100 protein-positive glial cells to injury within the neonatal rat brain. Neural cell adhesion molecule (N-CAM) inhibits astrocyte proliferation after harm to completely different areas of the adult rat brain. What used to take a Tricaster/Video Toaster setup can now be done in software program utilizing a standard PC. I can change backwards and forwards between instructor view, demonstration camera, audience view, presentation slide deck or video, etc… and it’s seamless.
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As a control, a peptide of the identical composition because the N-CAM decapeptide however of random sequence was infused on the contralateral facet of the brain. We constantly found that the population of dividing astrocytes was significantly smaller on the aspect by which N-CAM or one of the N-CAM-related molecules was infused than on the alternative aspect. The inhibition was greatest in the cortical lesion websites (approximately 50%) and was less pronounced in the hippocampus (approximately 25%) and striatum (approximately 20%). Two weeks after the lesion, the cerebral cortical websites infused with N-CAM continued to exhibit a considerably aex cam smaller population of dividing astrocytes than the sites on the alternative facet. When N-CAM and basic fibroblast progress factor, which is known to stimulate astrocyte division in vitro, were coinfused into cortical lesion websites, astrocyte proliferation was still inhibited. These outcomes suggest the hypothesis that, by reducing glial proliferation, N-CAM or its peptides may assist create an setting that is extra suitable for neuronal regeneration.
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